解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVE:To determine the best autoantibody-based testing strategy for recruiting relatives for future intervention trials and to establish the role of islet cell antibodies (ICAs) within this strategy. RESEARCH DESIGN AND METHODS:ICAs, insulin autoantibodies (IAAs), GAD antibodies, and IA-2 antibodies were determine...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.11.1796
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between the insertion (I)/deletion (D) polymorphism of the ACE gene and arterial distensibility in patients with type 2 diabetes and healthy control subjects. RESEARCH DESIGN AND METHODS:Aortic and carotid arterial distensibility were evaluated by measuring aortic pulse-wave veloci...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.11.1858
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:To develop and validate a scale for acanthosis nigricans (AN). RESEARCH DESIGN AND METHODS:Subjects were participants from the San Antonio Family Diabetes Study and the San Antonio Family Heart Study. A total of 406 subjects were independently examined for AN by at least two observers. Five locations were ex...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.10.1655
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare measurements of glucose obtained via iontophoretic extraction with the GlucoWatch automatic glucose biographer (Cygnus, Inc., Redwood City, CA) with capillary blood glucose values that were determined 1) in a controlled outpatient clinic setting and 2) in a home settin...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.22.10.1708
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:To examine the effects of hormone replacement therapy (HRT) on lipid metabolism, glycemic control, total body and central abdominal fat, blood pressure (BP), and arterial pulse wave velocity (APWV) in overweight postmenopausal females with type 2 diabetes. RESEARCH DESIGN AND METHODS:This was a 12-month pros...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.22.9.1401
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE:Several methods have been proposed to evaluate insulin sensitivity from the data obtained from the oral glucose tolerance test (OGTT). However, the validity of these indices has not been rigorously evaluated by comparing them with the direct measurement of insulin sensitivity obtained with the euglycemic insu...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.9.1462
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE:We previously demonstrated a direct correlation between serum insulin levels and gonadal androgens (testosterone and androstenedione) in a group of obese hyperandrogenic predominantly black women. Subsequent work by others in predominantly white women showed conflicting results. To examine these potentially i...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.22.9.1524
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE:To test the conclusion that there is no association between multiple episodes of severe hypoglycemia and cognitive decrements by reanalyzing the data from the Diabetes Control and Complications Trial (DCCT) with psychometrically validated cognitive factors and to conduct a novel analysis of the association be...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.8.1273
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:There is substantial evidence that glucose intolerance is associated with an increased risk of cardiovascular disease. However, it is not well established whether plasma glucose is independently related to atherosclerosis when glucose tolerance is normal and, if so, to which stage of the complex atherosclerot...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.8.1339
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:To determine whether folate metabolism in pregnant diabetic women is significantly different from that in pregnant nondiabetic women, thus predisposing them to having offspring with major congenital anomalies. RESEARCH DESIGN AND METHODS:A total of 31 pregnant diabetic women and 54 pregnant nondiabetic contr...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.7.1017
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between depressive symptoms and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS:In 1984, 2,764 male employees of an electrical company in Japan completed a self-administered questionnaire including the Zung Self-Rating Depression Scale (SDS). They were followed for t...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.7.1071
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:To examine counterregulatory responses during spontaneous nocturnal hypoglycemia in prepubertal children with type 1 diabetes. RESEARCH DESIGN AND METHODS:A total of 29 prepubertal patients with type 1 diabetes underwent two overnight profiles. Data were analyzed from 16 children (median [range] 8.7 [5.9-12....
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.7.1144
更新日期:1999-07-01 00:00:00
abstract::This commentary/review briefly considers the diverse criteria recommended for classification of overweight infants. Macrosomia continues to be a vexing problem for both obstetricians and pediatricians. Among the various techniques possible for use in assessing body composition, none are more practical than body weight...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.22.7.1201
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:Troglitazone was recently reported to specifically promote the differentiation of pre-adipocytes into adipocytes in vitro in subcutaneous fat only, indicating a relation to insulin-resistance-improving action of troglitazone. To expand on this finding, we investigated at the clinical level how long-term admin...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.22.6.908
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between diabetes characteristics, medical history, foot deformity, sensory neuropathy, and plantar foot pressure. RESEARCH DESIGN AND METHODS:There were 517 subjects from a cohort of diabetic veterans enrolled in a prospective study of risk factors for foot complications who contri...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.6.965
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:Physical activity is integral to the management of type 2 diabetes. Unfortunately, the majority of adults with type 2 diabetes do not regularly engage in physical activity. The purpose of this study was to assess physical activity behavior and its correlates (i.e., physical activity knowledge, barriers, and p...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.5.706
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:Our objective was to analyze the prevalence, incidence, and mortality of diabetes in a population of 280,539 inhabitants. RESEARCH DESIGN AND METHODS:The incidence, prevalence, and deaths from diabetes at all ages of a population have been prospectively followed in the county of Skaraborg, Sweden, since 1991...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.5.773
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To investigate whether peripheral neuropathy (PN), as part of the microangiopathic complex, affects bone mineral density (BMD) of the peripheral or the axial skeleton in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS:Three study groups were examined. Group 1 comprised 21 males with type 1 diabete...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.5.827
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of clinically obtainable improvements in metabolic control in patients with type 1 diabetes on biochemical cardiovascular risk factors. RESEARCH DESIGN AND METHODS:Blood and 24-h urinary samples were obtained from 49 patients with type 1 diabetes before and after a run-in period and af...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/diacare.22.4.546
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:Type 2 diabetes is a heterogeneous disease in which both beta-cell dysfunction and insulin resistance are pathogenetic factors. Disproportionate hyperproinsulinemia (elevated proinsulin/insulin) is another abnormality in type 2 diabetes whose mechanism is unknown. Increased demand due to obesity and/or insuli...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.4.609
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:Epidemiological evidence suggests that genetic factors can affect the course of type 1 diabetes complications produced by long-lasting hyperglycemia. In this review, the current strategies applicable to identifying these genetic factors are examined, as are recent findings on the genetics of diabetic nephropa...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:
更新日期:1999-03-01 00:00:00
abstract::Once daily injection of existing intermediate/long-acting insulin preparations does not provide a 24-h basal insulinemia in most patients. High variability, pronounced insulin peaks, and (as a result) a high risk of nocturnal hypoglycemia only poorly simulate normal physiology. One principle to prolong insulin action ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVE:Plasma leptin, an important signal for the regulation of energy stores, is known to be influenced by many hormonal factors, but may also be affected by behavioral and environmental factors. The purpose of this study was to investigate the impact of lifestyle (diet composition, level of physical activity) on p...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.3.413
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVE:Repaglinide is a newly developed oral blood glucose-lowering agent that exerts its effect by stimulating insulin secretion. This multicenter study was designed to compare the efficacy and safety of this drug with glyburide in a 1-year randomized double-blind study of outpatients with type 2 diabetes. RESEARC...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.22.3.463
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVE:The purpose of the 1992 Singapore National Health Survey was to determine the current distribution of major noncommunicable diseases and their risk factors, including the prevalence of diabetes and dyslipidemia, in Singapore. RESEARCH DESIGN AND METHODS:A combination of disproportionate stratified sampling a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.2.241
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVE:To compare albumin-to-creatinine ratio (ACR) and albumin concentration (ALB) for detection of microalbuminuria using precise data on CIs for sensitivity and specificity and to determine sex- and age-specific discriminator values for ACR. RESEARCH DESIGN AND METHODS:All consecutive patients investigated for t...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.2.307
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVE:The results differ concerning randomized controlled trials of the effects of metformin on blood glucose regulation and body weight. To get a systematic overview, a meta-analysis of the efficacy of metformin was performed by comparing metformin with placebo and sulfonylurea. RESEARCH DESIGN AND METHODS:All ra...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析
doi:10.2337/diacare.22.1.33
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:The Diabetes Control and Complications Trial (DCCT) demonstrated the powerful impact of glycemic control on the early manifestations of microvascular complications. Contemporary prospective data on the evolution of macrovascular and late microvascular complications of type 1 diabetes are limited. The Epidemio...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.22.1.99
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To assess the effect of mixing the insulin analog lispro (Humalog) with NPH (Humulin I) before injection on lispro's fast, short action profile. RESEARCH DESIGN AND METHODS:A total of 12 healthy volunteers received subcutaneous abdominal injections of 0.1 U/kg regular insulin and 0.2 U/kg NPH insulin as foll...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.21.12.2098
更新日期:1998-12-01 00:00:00
abstract::Epidemiological studies performed over the past 40 years have shown that the prevalence of diagnosed diabetes has increased dramatically in the U.S. and that a substantial proportion of the population has undiagnosed diabetes, impaired fasting glucose, and impaired glucose tolerance. Diabetes is most prevalent in mino...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.3.c11
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:To explore mechanisms for hypertriglyceridemia in diabetic patients with microalbuminuria, we examined an association between heparin-releasable lipoprotein lipase (LPL) and the von Willebrand factor (vWF), based on the hypothesis that LPL bound to endothelium is decreased by generalized endothelial damage. ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.11.2016
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:Biomechanical studies in diabetic neuropathy have clearly demonstrated abnormal foot pressures, but information on other aspects of gait is limited. This study aimed to investigate and describe the forces transmitted through the foot during walking in diabetic subjects with varying degrees of peripheral neuro...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.11.1955
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:The objective of the study was to assess the efficacy and safety of repaglinide compared with placebo in the treatment of patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:This was a phase II multicenter, double-blind, placebo-controlled, randomized, dose-adjustment and maintenance trial. After scre...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2337/diacare.21.11.1897
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:Prior studies have supported that waist circumference correlates better with visceral adipose tissue and is a better predictor of cardiovascular disease than are BMI and waist-to-hip ratio. In this study, we reexamine the role of waist size on the risk of hypertension and type 2 diabetes in African-origin pop...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.11.1836
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:In diabetes, the persistence of hyperglycemia has been reported to cause increased production of oxygen free radicals through glucose autooxidation and nonenzymatic glycation. The aim of this study was to determine whether oxidative cellular damage occurs at the clinical onset of diabetes and in later stages ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.10.1736
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:The main purpose of this work was to study the possible differences in insulin secretion in a large group of type 2 diabetic patients in relation to diabetes duration, obesity, and the presence of secondary failure after treatment with oral hypoglycemic agents. RESEARCH DESIGN AND METHODS:There were 147 nono...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.10.1680
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:The monosaccharides resulting from the digestion of ingested carbohydrates are glucose, fructose, and galactose. Of these three monosaccharides, only ingested glucose resulted in a large increase in the plasma glucose concentration. Fructose (Metabolism 41:510-517, 1992) and galactose (Metabolism 42:1560-1567...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.21.10.1619
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:Although persistent hyperglycemia contributes greatly to the progression of diabetic micro- and macroangiopathy, microangiopathy progresses more rapidly than macroangiopathy in some type 2 diabetic patients, with the opposite being true in others. This study was conducted to identify factors responsible for s...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.9.1451
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To study the effect of vitamin E supplementation on platelet hyperaggregability in type 1 diabetic patients. RESEARCH DESIGN AND METHODS:Written informed consent according to the Institutional Review Board on Human Experimentation guidelines was obtained from diabetic patients (n = 29) and their age-matched ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.21.9.1511
更新日期:1998-09-01 00:00:00
abstract::The concept of gestational diabetes goes back at least to 1946. Over the years, sophistication has increased regarding the pathophysiology of this condition. However, there is not universal agreement on how to diagnose gestational diabetes. The most widely used diagnostic criteria in the U.S. were validated by their p...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:
更新日期:1998-08-01 00:00:00